If you tell God no because He won't explain the reason He wants you to do something you are actually hindering His blessing. But when you say yes to Him all of heaven opens to pour out His goodness and reward your obedience. What matters more than material blessings are the things He is teaching us in our spirit.
My top most priority is to deal with India's massive social and economic problems so that chronic poverty ignorance and disease can be conquered in a reasonably short period of time.