If your goal is anything but profitability - if it's to be big or to grow fast or to become a technology leader - you'll hit problems.
The underlying principles of strategy are enduring regardless of technology...
If we had had the right technology back then you would have seen Eva Braun...
I had a very famous trainer tell me once 'You can usually train a wild animal but never tame a wild animal ever.' They are always going to be wild no matter what anybody says.